Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection

Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection

Autoreactive T cells are deleted in the thymus via thymic negative selection and Bim-mediated apoptosis. Here the authors identify a cis-acting enhancer, E BAB , that is essential for proper Bim expression and apoptosis induction, and show that E BAB deficiency specifically impairs thymic negative s...

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Bibliographic Details
Main Authors: Miki Arai Hojo, Kyoko Masuda, Hiroaki Hojo, Yosuke Nagahata, Keiko Yasuda, Daiya Ohara, Yusuke Takeuchi, Keiji Hirota, Yutaka Suzuki, Hiroshi Kawamoto, Shinpei Kawaoka
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10525-1

Internet

https://doi.org/10.1038/s41467-019-10525-1

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