Voluntary wheel running reverses age-induced changes in hippocampal gene expression.

Normal aging alters expression of numerous genes within the brain. Some of these transcription changes likely contribute to age-associated cognitive decline, reduced neural plasticity, and the higher incidence of neuropathology. Identifying factors that modulate brain aging is crucial for improving...

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Bibliographic Details
Main Authors: Rachel A Kohman, Sandra L Rodriguez-Zas, Bruce R Southey, Keith W Kelley, Robert Dantzer, Justin S Rhodes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3152565?pdf=render