Iminosugars: Effects of Stereochemistry, Ring Size, and <i>N</i>-Substituents on Glucosidase Activities

Iminosugars: Effects of Stereochemistry, Ring Size, and <i>N</i>-Substituents on Glucosidase Activities

<i>N</i>-substituted iminosugar analogues are potent inhibitors of glucosidases and glycosyltransferases with broad therapeutic applications, such as treatment of diabetes and Gaucher disease, immunosuppressive activities, and antibacterial and antiviral effects against HIV, HPV, hepatit...

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Bibliographic Details
Main Authors: Luís O. B. Zamoner, Valquiria Aragão-Leoneti, Ivone Carvalho
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Pharmaceuticals
Subjects:
iminosugars
polyhydroxypiperidines
polyhydroxyazepanes
glucosidase inhibition
miglustat
miglitol
Online Access:https://www.mdpi.com/1424-8247/12/3/108

Internet

https://www.mdpi.com/1424-8247/12/3/108

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