Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors.

Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors.

The regulation of translation initiation factor 2 (eIF2) is important for erythroid survival and differentiation. Lack of iron, a critical component of heme and hemoglobin, activates Heme Regulated Inhibitor (HRI). This results in phosphorylation of eIF2 and reduced eIF2 availability, which inhibits...

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Bibliographic Details
Main Authors: Nahuel A Paolini, Kat S Moore, Franca M di Summa, Ivo F A C Fokkema, Peter A C 't Hoen, Marieke von Lindern
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5892948?pdf=render

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http://europepmc.org/articles/PMC5892948?pdf=render

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