SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway.

Bibliographic Details
Main Authors: Emilia Mira, Lorena Carmona-Rodríguez, Beatriz Pérez-Villamil, Josefina Casas, María Jesús Fernández-Aceñero, Diego Martínez-Rey, Paula Martín-González, Ignacio Heras-Murillo, Mateo Paz-Cabezas, Manuel Tardáguila, Tim D. Oury, Silvia Martín-Puig, Rosa Ana Lacalle, Gemma Fabriás, Eduardo Díaz-Rubio, Santos Mañes
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03079-1

Internet

https://doi.org/10.1038/s41467-018-03079-1

Similar Items