Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin.

Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin.

Cyto-nuclear shuttling of β-catenin is at the epicenter of the canonical Wnt pathway and mutations in genes that result in excessive nuclear accumulation of β-catenin are the driving force behind the initiation of many cancers. Recently, Naked Cuticle homolog 1 (Nkd1) has been identified as a Wnt-in...

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Bibliographic Details
Main Authors: Terence J Van Raay, Nicholas J Fortino, Bryan W Miller, Haiting Ma, Garnet Lau, Cunxi Li, Jeffery L Franklin, Liliana Attisano, Lilianna Solnica-Krezel, Robert J Coffey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3072412?pdf=render

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http://europepmc.org/articles/PMC3072412?pdf=render

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