Biochemical determinants of the IGFBP‐3–hyaluronan interaction

Biochemical determinants of the IGFBP‐3–hyaluronan interaction

IGFBP‐3, the most abundant IGFBP and the main carrier of insulin‐like growth factor I (IGF‐I) in the circulation, can bind IGF‐1 with high affinity, which attenuates IGF/IGF‐IR interactions, thereby resulting in antiproliferative effects. The C‐terminal domain of insulin‐like growth factor‐binding p...

Full description

Bibliographic Details
Main Authors: Sadaf Dorandish, Jonathan Devos, Bradley Clegg, Deanna Price, Robert Muterspaugh, Jeffrey Guthrie, Deborah L. Heyl, Hedeel Guy Evans
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:FEBS Open Bio
Subjects:
CD44
humanin
hyaluronan
IGFBP‐3
kinetics
peptide
Online Access:https://doi.org/10.1002/2211-5463.12919

Internet

https://doi.org/10.1002/2211-5463.12919

Similar Items