The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells

The Novel Phosphatidylinositol-3-Kinase (PI3K) Inhibitor Alpelisib Effectively Inhibits Growth of PTEN-Haploinsufficient Lipoma Cells

Germline mutations in the tumor suppressor gene <i>PTEN</i> cause PTEN Hamartoma Tumor Syndrome (PHTS). Pediatric patients with PHTS frequently develop lipomas. Treatment attempts with the mTORC1 inhibitor rapamycin were unable to reverse lipoma growth. Recently, lipomas associated with...

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Bibliographic Details
Main Authors: Anna S. Kirstein, Adrien Augustin, Melanie Penke, Michele Cea, Antje Körner, Wieland Kiess, Antje Garten
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
mtor
akt
phts
pros
lipoma
rapamycin
overgrowth
proliferation
spheroids
ribosomal protein s6
Online Access:https://www.mdpi.com/2072-6694/11/10/1586

Internet

https://www.mdpi.com/2072-6694/11/10/1586

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