Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag

The HIV-1 Gag p6 protein regulates the final abscission step of nascent virions from the cell membrane by the action of its two late (l-) domains, which recruit Tsg101 and ALIX, components of the ESCRT system. Even though p6 consists of only 52 amino acids, it is encoded by one of the most polymorph...

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Bibliographic Details
Main Authors: Melanie Friedrich, Christian Setz, Friedrich Hahn, Alina Matthaei, Kirsten Fraedrich, Pia Rauch, Petra Henklein, Maximilian Traxdorf, Torgils Fossen, Ulrich Schubert
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/8/4/117