Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study

Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study

Background: Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was evidence of subtle neurodegeneration. Here, we u...

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Bibliographic Details
Main Authors: Eileanoir B. Johnson, Christopher S. Parker, Rachael I. Scahill, Sarah Gregory, Marina Papoutsi, Paul Zeun, Katherine Osborne-Crowley, Jessica Lowe, Akshay Nair, Carlos Estevez-Fraga, Kate Fayer, Geraint Rees, Hui Zhang, Sarah J. Tabrizi
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:EBioMedicine
Subjects:
Huntington's disease
MRI
Microstructure
Iron
Myelin
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421000591

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http://www.sciencedirect.com/science/article/pii/S2352396421000591

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