Thymic crosstalk coordinates medulla organization and T-cell tolerance induction

Thymic crosstalk coordinates medulla organization and T-cell tolerance induction

The thymus ensures the generation of a functional and highly diverse T-cell repertoire. The thymic medulla, which is mainly composed of medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), provides a specialized microenvironment dedicated to the establishment of T-cell tolerance. mTE...

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Bibliographic Details
Main Authors: Noëlla eLopes, Arnauld eSergé, Pierre eFerrier, Magali eIrla
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Immunology
Subjects:
medulla
Dendritic cells (DCs)
T-cell tolerance
negative selection
thymic crosstalk
Medullary thymic epithelial cells (mTECs)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00365/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00365/full

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