Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis

Targeting S100A4 with niclosamide attenuates inflammatory and profibrotic pathways in models of amyotrophic lateral sclerosis

Abstract Background An increasing number of studies evidences that amyotrophic lateral sclerosis (ALS) is characterized by extensive alterations in different cell types and in different regions besides the CNS. We previously reported the upregulation in ALS models of a gene called fibroblast-specifi...

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Bibliographic Details
Main Authors: Martina Milani, Eleonora Mammarella, Simona Rossi, Chiara Miele, Serena Lattante, Mario Sabatelli, Mauro Cozzolino, Nadia D’Ambrosi, Savina Apolloni
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Neuroinflammation
Subjects:
ALS
S100A4
Fibroblasts
FUS
α-SMA
Neurodegeneration
Online Access:https://doi.org/10.1186/s12974-021-02184-1

Internet

https://doi.org/10.1186/s12974-021-02184-1

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