Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

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The identity of the glioblastoma (GBM) cell of origin and its contributions to disease progression and treatment response remain largely unknown. We have analyzed how the phenotypic state of the initially transformed cell affects mouse GBM development and essential GBM cell (GC) properties. We find...

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Bibliographic Details
Main Authors: Yiwen Jiang, Voichita Dana Marinescu, Yuan Xie, Malin Jarvius, Naga Prathyusha Maturi, Caroline Haglund, Sara Olofsson, Nanna Lindberg, Tommie Olofsson, Caroline Leijonmarck, Göran Hesselager, Irina Alafuzoff, Mårten Fryknäs, Rolf Larsson, Sven Nelander, Lene Uhrbom
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
glioblastoma
glioma
cancer stem cell
cell of origin
neural stem cell
oligodendrocyte precursor cell
self-renewal
mouse model
drug response
central nervous system
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300219

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http://www.sciencedirect.com/science/article/pii/S2211124717300219

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