Search for Antimicrobial Activity Among Fifty-Two Natural and Synthetic Compounds Identifies Anthraquinone and Polyacetylene Classes That Inhibit Mycobacterium tuberculosis

Search for Antimicrobial Activity Among Fifty-Two Natural and Synthetic Compounds Identifies Anthraquinone and Polyacetylene Classes That Inhibit Mycobacterium tuberculosis

Drug-resistant tuberculosis threatens to undermine global control programs by limiting treatment options. New antimicrobial drugs are required, derived from new chemical classes. Natural products offer extensive chemical diversity and inspiration for synthetic chemistry. Here, we isolate, synthesize...

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Bibliographic Details
Main Authors: Luiz A. E. Pollo, Erlon F. Martin, Vanessa R. Machado, Daire Cantillon, Leticia Muraro Wildner, Maria Luiza Bazzo, Simon J. Waddell, Maique W. Biavatti, Louis P. Sandjo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
drug discovery
natural product
synthetic polyacetylenes
antimicrobial drug resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.622629/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.622629/full

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