Decreased SFRP5 correlated with excessive metabolic inflammation in polycystic ovary syndrome could be reversed by metformin: implication of its role in dysregulated metabolism

Decreased SFRP5 correlated with excessive metabolic inflammation in polycystic ovary syndrome could be reversed by metformin: implication of its role in dysregulated metabolism

Abstract Background Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder of heterogeneous nature. Secreted frizzled-related protein (SFRP) 5 is an anti-inflammatory adipokine implicated in metabolic homeostasis. We aimed to confirm the correlation between SFRP5, metabolic inflammation an...

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Bibliographic Details
Main Authors: Yi Zhang, Yuxin Ran, Lingna Kong, Lihong Geng, Hua Huang, Hongying Zhang, Jun Hu, Hongbo Qi, Ying Chen
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Journal of Ovarian Research
Subjects:
Polycystic ovary syndrome (PCOS)
Secreted frizzled-related protein (SFRP) 5
Inflammation
Metformin
Hyperandrogenism (HA)
Online Access:https://doi.org/10.1186/s13048-021-00847-4

Internet

https://doi.org/10.1186/s13048-021-00847-4

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