Coexisting EGFR and TP53 Mutations in Lung Adenocarcinoma Patients Are Associated With COMP and ITGB8 Upregulation and Poor Prognosis

Coexisting EGFR and TP53 Mutations in Lung Adenocarcinoma Patients Are Associated With COMP and ITGB8 Upregulation and Poor Prognosis

The heterogeneity of lung adenocarcinoma is driven by key mutations in oncogenes. To determine the gene expression, single nucleotide polymorphisms, and co-mutations participating in the initiation and progression of lung adenocarcinoma, we comprehensively analyzed the data of 491 patients from The...

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Bibliographic Details
Main Authors: Chang Zheng, Xuelian Li, Yangwu Ren, Zhihua Yin, Baosen Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
co-mutation
EGFRL858R
TP53
gene interaction
COMP
ITGB8
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00030/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00030/full

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