T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment

T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment

A better understanding of early brain changes that precede loss of independence in diseases like Alzheimer's disease (AD) is critical for development of disease-modifying therapies. Quantitative MRI, such as T2 relaxometry, can identify microstructural changes relevant to early stages of pathol...

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Bibliographic Details
Main Authors: Alfie R. Wearn, Volkan Nurdal, Esther Saunders-Jennings, Michael J. Knight, Christopher R. Madan, Sean-James Fallon, Hanna K. Isotalus, Risto A. Kauppinen, Elizabeth J. Coulthard
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:NeuroImage
Subjects:
Magnetic resonance imaging
Alzheimer's disease
Early diagnosis
Ageing
Hippocampal subfields
Medial temporal lobe
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811921004912

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http://www.sciencedirect.com/science/article/pii/S1053811921004912

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