Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

Objective: Pancreatic β-cell failure is central to the development and progression of type 2 diabetes (T2D). The aggregation of human islet amyloid polypeptide (hIAPP) has been associated with pancreatic islet inflammation and dysfunction in T2D. Alpha1-antitrypsin (AAT) is a circulating protease in...

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Bibliographic Details
Main Authors: Júlia Rodríguez-Comas, Juan Moreno-Vedia, Mercè Obach, Carlos Castaño, Sara de Pablo, Gema Alcarraz-Vizán, Daniela Díaz-Catalán, Anna Mestre, Raquel Horrillo, Montserrat Costa, Anna Novials, Joan-Marc Servitja
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Molecular Metabolism
Subjects:
β-Cell
Macrophage
IAPP
Amyloid
Islet inflammation
Alpha1-antitrypsin
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300582

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http://www.sciencedirect.com/science/article/pii/S2212877820300582

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