Design and Characterization of an “All-in-One” Lentiviral Vector System Combining Constitutive Anti-G<sub>D2</sub> CAR Expression and Inducible Cytokines

Design and Characterization of an “All-in-One” Lentiviral Vector System Combining Constitutive Anti-G<sub>D2</sub> CAR Expression and Inducible Cytokines

Genetically modified T cells expressing chimeric antigen receptors (CARs) so far have mostly failed in the treatment of solid tumors owing to a number of limitations, including an immunosuppressive tumor microenvironment and insufficient CAR T cell activation and persistence. Next-generation approac...

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Bibliographic Details
Main Authors: Katharina Zimmermann, Johannes Kuehle, Anna Christina Dragon, Melanie Galla, Christina Kloth, Loreen Sophie Rudek, I. Erol Sandalcioglu, Belal Neyazi, Thomas Moritz, Johann Meyer, Claudia Rossig, Bianca Altvater, Britta Eiz-Vesper, Michael Alexander Morgan, Hinrich Abken, Axel Schambach
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
glioblastoma
“all-in-one” lentiviral vector
truck
g<sub>d2</sub>car
nfat
inducible cytokines
il12
il18
Online Access:https://www.mdpi.com/2072-6694/12/2/375

Internet

https://www.mdpi.com/2072-6694/12/2/375

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