In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity

In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity

Abstract Nanotechnologies are considered to be of growing importance to the vaccine field. Through decoration of immunogens on multivalent nanoparticles, designed nanovaccines can elicit improved humoral immunity. However, significant practical and monetary challenges in large‐scale production of na...

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Bibliographic Details
Main Authors: Ziyang Xu, Megan C. Wise, Neethu Chokkalingam, Susanne Walker, Edgar Tello‐Ruiz, Sarah T. C. Elliott, Alfredo Perales‐Puchalt, Peng Xiao, Xizhou Zhu, Ruth A. Pumroy, Paul D. Fisher, Katherine Schultheis, Eric Schade, Sergey Menis, Stacy Guzman, Hanne Andersen, Kate E. Broderick, Laurent M. Humeau, Kar Muthumani, Vera Moiseenkova‐Bell, William R. Schief, David B. Weiner, Daniel W. Kulp
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Advanced Science
Subjects:
DNA vaccines
in vivo self‐assembly
infectious diseases
nanoparticle vaccines
protein engineering
Online Access:https://doi.org/10.1002/advs.201902802

Internet

https://doi.org/10.1002/advs.201902802

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