Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

Disease monitoring of chronic lymphocytic leukaemia (CLL) is a challenge. Here, the authors show that serial ctDNA analysis in 32 CLL patients allows monitoring of clonal dynamics over time, and identifies the emergence of genomic changes associated with Richter’s syndrome.

Bibliographic Details
Main Authors: Paul Yeh, Tane Hunter, Devbarna Sinha, Sarah Ftouni, Elise Wallach, Damian Jiang, Yih-Chih Chan, Stephen Q. Wong, Maria Joao Silva, Ravikiran Vedururu, Kenneth Doig, Enid Lam, Gisela Mir Arnau, Timothy Semple, Meaghan Wall, Andjelija Zivanovic, Rishu Agarwal, Pasquale Petrone, Kate Jones, David Westerman, Piers Blombery, John F. Seymour, Anthony T. Papenfuss, Mark A. Dawson, Constantine S. Tam, Sarah-Jane Dawson
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14756

Internet

https://doi.org/10.1038/ncomms14756

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