Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene

Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene

Abstract Background In acute lymphoblastic leukemia (ALL), high ABCB1 gene expression has been associated with treatment resistance, which affects patient prognosis. Many preclinical reports and retrospective population studies have shown an anti-cancer effect of metformin. Therefore, the objective...

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Main Authors: Christian Ramos-Peñafiel, Irma Olarte-Carrillo, Rafael Cerón-Maldonado, Etta Rozen-Fuller, Juan Julio Kassack-Ipiña, Guillermo Meléndez-Mier, Juan Collazo-Jaloma, Adolfo Martínez-Tovar
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Translational Medicine
Subjects:
ATP binding cassette subfamily B member 1 (ABCB1)
Quantitative real-time polymerase chain reaction (qRT-PCR)
Acute lymphoblastic leukemia (ALL)
Online Access:http://link.springer.com/article/10.1186/s12967-018-1620-6

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http://link.springer.com/article/10.1186/s12967-018-1620-6

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