Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under vete...

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Bibliographic Details
Main Authors: Federica Giordani, Daniel Paape, Isabel M Vincent, Andrew W Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J Morrison, Yvonne Freund, Michael J Witty, Rosemary Peter, Darren Y Edwards, Jonathan M Wilkes, Justin J J van der Hooft, Clément Regnault, Kevin D Read, David Horn, Mark C Field, Michael P Barrett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008932

Internet

https://doi.org/10.1371/journal.ppat.1008932

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