A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy

A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy

The Zika virus (ZIKV) has recently attracted major research interest as infection was unexpectedly associated with neurological manifestations in developing foetuses and with Guillain-Barré syndrome in infected adults. Understanding the underlying molecular mechanisms requires reverse genetic syste...

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Bibliographic Details
Main Authors: Maximilian Münster, Anna Płaszczyca, Mirko Cortese, Christopher John Neufeldt, Sarah Goellner, Gang Long, Ralf Bartenschlager
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Viruses
Subjects:
ZIKV
reporter virus
cryptic promoter silencing
full-length molecular clone
subgenomic replicon
plasmid toxicity
Online Access:http://www.mdpi.com/1999-4915/10/7/368

Internet

http://www.mdpi.com/1999-4915/10/7/368

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