Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection

Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection

Investigating the dynamics of virus-host interactions in vivo remains an important challenge, often limited by the ability to directly identify virally infected cells. Here, we utilize a beta-lactamase activated fluorescent substrate to identify primary targets of murine gammaherpesvirus 68 (MHV68)...

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Bibliographic Details
Main Authors: Julianne B. Riggs, Eva M. Medina, Loni J. Perrenoud, Diana L. Bonilla, Eric T. Clambey, Linda F. van Dyk, Leslie J. Berg
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Microbiology
Subjects:
gammaherpesvirus
macrophages
peritoneal cavity
latency
reporter virus
multiparameter flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.656979/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2021.656979/full

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