Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and Hepatoblastoma
Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem cells (CSCs) pl...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-12-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/14/12/24706 |
id |
doaj-a5dd374c64ab4d9e976f4af2994bdc60 |
---|---|
record_format |
Article |
spelling |
doaj-a5dd374c64ab4d9e976f4af2994bdc602020-11-24T21:07:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-12-011412247062472510.3390/ijms141224706ijms141224706Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and HepatoblastomaAnna Alisi0William C. Cho1Franco Locatelli2Doriana Fruci3Liver Research Unit, "Bambino Gesù" Children's Hospital, IRCCS, Rome 00165, ItalyDepartment of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, ChinaDepartment of Oncohematology, "Bambino Gesù" Children's Hospital, IRCCS, Rome 00165, ItalyDepartment of Oncohematology, "Bambino Gesù" Children's Hospital, IRCCS, Rome 00165, ItalyChemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem cells (CSCs) play a role as master regulators. Therefore, understanding the mechanisms that regulate some traits of CSCs may help design efficient strategies to overcome chemoresistance. Different CSC phenotypes have been identified, including those found in some pediatric malignancies. As solid tumors in children significantly differ from those observed in adults, this review aims at providing an overview of the mechanistic relationship between MDR and CSCs in common solid tumors, and, in particular, focuses on clinical as well as experimental evidence of the relations between CSCs and MDR in neuroblastoma and hepatoblastoma. Finally, some novel approaches, such as concomitant targeting of multiple key transcription factors governing the stemness of CSCs, as well as nanoparticle-based approaches will also be briefly addressed.http://www.mdpi.com/1422-0067/14/12/24706cancer stem cellsmultidrug resistanceneuroblastomahepatoblastoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anna Alisi William C. Cho Franco Locatelli Doriana Fruci |
spellingShingle |
Anna Alisi William C. Cho Franco Locatelli Doriana Fruci Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and Hepatoblastoma International Journal of Molecular Sciences cancer stem cells multidrug resistance neuroblastoma hepatoblastoma |
author_facet |
Anna Alisi William C. Cho Franco Locatelli Doriana Fruci |
author_sort |
Anna Alisi |
title |
Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and Hepatoblastoma |
title_short |
Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and Hepatoblastoma |
title_full |
Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and Hepatoblastoma |
title_fullStr |
Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and Hepatoblastoma |
title_full_unstemmed |
Multidrug Resistance and Cancer Stem Cells in Neuroblastoma and Hepatoblastoma |
title_sort |
multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2013-12-01 |
description |
Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem cells (CSCs) play a role as master regulators. Therefore, understanding the mechanisms that regulate some traits of CSCs may help design efficient strategies to overcome chemoresistance. Different CSC phenotypes have been identified, including those found in some pediatric malignancies. As solid tumors in children significantly differ from those observed in adults, this review aims at providing an overview of the mechanistic relationship between MDR and CSCs in common solid tumors, and, in particular, focuses on clinical as well as experimental evidence of the relations between CSCs and MDR in neuroblastoma and hepatoblastoma. Finally, some novel approaches, such as concomitant targeting of multiple key transcription factors governing the stemness of CSCs, as well as nanoparticle-based approaches will also be briefly addressed. |
topic |
cancer stem cells multidrug resistance neuroblastoma hepatoblastoma |
url |
http://www.mdpi.com/1422-0067/14/12/24706 |
work_keys_str_mv |
AT annaalisi multidrugresistanceandcancerstemcellsinneuroblastomaandhepatoblastoma AT williamccho multidrugresistanceandcancerstemcellsinneuroblastomaandhepatoblastoma AT francolocatelli multidrugresistanceandcancerstemcellsinneuroblastomaandhepatoblastoma AT dorianafruci multidrugresistanceandcancerstemcellsinneuroblastomaandhepatoblastoma |
_version_ |
1716761470096637952 |