Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

Adipose tissue hypertrophy in obesity is associated with insulin resistance and other metabolic complications. Here, the authors analyze subcutaneous adipose tissue from patients with hypertrophic obesity and insulin resistance and find that adipocyte progenitor cells show features of senescence and...

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Bibliographic Details
Main Authors: Birgit Gustafson, Annika Nerstedt, Ulf Smith
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10688-x