Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation

Overexpression of miR-125b in Osteoblasts Improves Age-Related Changes in Bone Mass and Quality through Suppression of Osteoclast Formation

We recently reported an unexpected role of osteoblast-derived matrix vesicles in the delivery of microRNAs to bone matrix. Of such microRNAs, we found that miR-125b inhibited osteoclast formation by targeting <i>Prdm1</i> encoding a transcriptional repressor of anti-osteoclastogenesis fa...

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Bibliographic Details
Main Authors: Shota Ito, Tomoko Minamizaki, Shohei Kohno, Yusuke Sotomaru, Yoshiaki Kitaura, Shinsuke Ohba, Toshie Sugiyama, Jane E. Aubin, Kotaro Tanimoto, Yuji Yoshiko
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
miR-125b
matrix vesicles
bone development and aging
fracture healing
Online Access:https://www.mdpi.com/1422-0067/22/13/6745

Internet

https://www.mdpi.com/1422-0067/22/13/6745

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