The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson’s Disease

The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson’s Disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease, characterized by progressive bradykinesia, rigidity, resting tremor, and gait impairment, as well as a spectrum of non-motor symptoms including autonomic and cognitive dysfunction. The cardinal motor symptoms of PD stem fr...

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Bibliographic Details
Main Authors: Georgia Minakaki, Dimitri Krainc, Lena F. Burbulla
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
alpha-synuclein
calcium
dopamine
mitochondria
iron
Parkinson’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.580634/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.580634/full

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