Overexpression of CD6 and PD-1 Identifies Dysfunctional CD8+ T-Cells During Chronic SIV Infection of Rhesus Macaques

Overexpression of CD6 and PD-1 Identifies Dysfunctional CD8+ T-Cells During Chronic SIV Infection of Rhesus Macaques

Effective CD8+ T-cell responses play an important role in determining the course of SIV/HIV viral infection. Here we identified a unique population of dysfunctional CD8+ T-cells in lymphoid tissues and bronchoalveolar lavage (BAL) of rhesus macaques with chronic SIV infection characterized by co-exp...

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Bibliographic Details
Main Authors: Gospel Enyindah-Asonye, Anthony Nwankwo, Mohammad Arif Rahman, Ruth Hunegnaw, Christopher Hogge, Sabrina Helmold Hait, Eun-Ju Ko, Tanya Hoang, Marjorie Robert-Guroff
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
rhesus macaque
simian immunodeficiency virus
T-cell exhaustion
CD6
PD-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03005/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03005/full

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