Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays

Botulinum neurotoxins (BoNTs) are potent neurotoxins produced by bacteria, which inhibit neurotransmitter release, specifically in their physiological target known as motor neurons (MNs). For the potency assessment of BoNTs produced for treatment in traditional and aesthetic medicine, the mouse leth...

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Bibliographic Details
Main Authors: Maren Schenke, Brit-Maren Schjeide, Gerhard P. Püschel, Bettina Seeger
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/12/5/276