Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, is one of the most lethal human diseases. PDAC is now the fourth leading cause of cancer mortality in both men and women and deaths due to PDAC are projected to increase dramatically. Novel targets and agents for ch...

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Bibliographic Details
Main Author: Enrique eRozengurt
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-09-01
Series:Frontiers in Physiology
Subjects:
Akt
PKC
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00357/full