RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids

RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids

Summary: RNA-DNA hybrids are tightly regulated to ensure genome integrity. The RNase H enzymes RNase H1 and H2 contribute to chromosomal stability through the removal of RNA-DNA hybrids. Loss of RNase H2 function is implicated in human diseases of the nervous system and cancer. To better understand...

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Bibliographic Details
Main Authors: Arianna Lockhart, Vanessa Borges Pires, Fabio Bento, Vanessa Kellner, Sarah Luke-Glaser, George Yakoub, Helle D. Ulrich, Brian Luke
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471931441X

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http://www.sciencedirect.com/science/article/pii/S221112471931441X

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