Quality control in the apoA-I secretory pathway

Quality control in the apoA-I secretory pathway

From a total of 47 known apolipoprotein A-I (apoA-I) mutations, only 18 are linked to low plasma HDL apoA-I concentrations, and 78% of these map to apoA-I helices 6 and 7 (residues 143–186). Gene transfer and transgenic mouse studies have shown that several helix 6 apoA-I mutations have reduced hepa...

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Bibliographic Details
Main Authors: Shaila Bhat, Manal Zabalawi, Mark C. Willingham, Gregory S. Shelness, Michael J. Thomas, Mary G. Sorci-Thomas
Format: Article
Language:English
Published: Elsevier 2004-07-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein A-I
high density lipoprotein
mutant apolipoprotein A-I
protein secretion
quality control pathway
aggresomes
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317776

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http://www.sciencedirect.com/science/article/pii/S0022227520317776

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