Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins

Pentatricopeptide repeat proteins bind single-stranded RNA and have been used to study ssRNA biology. Here the authors co-opt these proteins to target ssDNA and demonstrate specific binding of telomere sequences, the structural basis for ssDNA wrapping, and use them as potent telomerase inhibitors.

Bibliographic Details
Main Authors: Henrik Spåhr, Tiongsun Chia, James P. Lingford, Stefan J. Siira, Scott B. Cohen, Aleksandra Filipovska, Oliver Rackham
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04388-1