Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
Pentatricopeptide repeat proteins bind single-stranded RNA and have been used to study ssRNA biology. Here the authors co-opt these proteins to target ssDNA and demonstrate specific binding of telomere sequences, the structural basis for ssDNA wrapping, and use them as potent telomerase inhibitors.
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04388-1 |