Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

Kinase inhibitors are effective cancer therapies, but tumors frequently develop resistance. Current strategies to circumvent resistance target the same or parallel pathways. We report here that targeting a completely different process, autophagy, can overcome multiple BRAF inhibitor resistance mecha...

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Bibliographic Details
Main Authors: Jean M Mulcahy Levy, Shadi Zahedi, Andrea M Griesinger, Andrew Morin, Kurtis D Davies, Dara L Aisner, BK Kleinschmidt-DeMasters, Brent E Fitzwalter, Megan L Goodall, Jacqueline Thorburn, Vladimir Amani, Andrew M Donson, Diane K Birks, David M Mirsky, Todd C Hankinson, Michael H Handler, Adam L Green, Rajeev Vibhakar, Nicholas K Foreman, Andrew Thorburn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
autophagy
BRAF V600E
brain tumor
chloroquine
pediatric
Online Access:https://elifesciences.org/articles/19671

Internet

https://elifesciences.org/articles/19671

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