A functional analysis of the spacer of V(D)J recombination signal sequences.

During lymphocyte development, V(D)J recombination assembles antigen receptor genes from component V, D, and J gene segments. These gene segments are flanked by a recombination signal sequence (RSS), which serves as the binding site for the recombination machinery. The murine Jbeta2.6 gene segment i...

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Bibliographic Details
Main Authors: Alfred Ian Lee, Sebastian D Fugmann, Lindsay G Cowell, Leon M Ptaszek, Garnett Kelsoe, David G Schatz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2003-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC212687?pdf=render