Pancreatic Islets Exhibit Dysregulated Adaptation of Insulin Secretion after Chronic Epinephrine Exposure

Pancreatic Islets Exhibit Dysregulated Adaptation of Insulin Secretion after Chronic Epinephrine Exposure

Chronic adrenergic stimulation is the dominant factor in impairment of the β-cell function. Sustained adrenergic exposure generates dysregulated insulin secretion in fetal sheep. Similar results have been shown in Min6 under the elevated epinephrine condition, but impairments after adrenergic remova...

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Bibliographic Details
Main Authors: Rui Li, Huichai Huang, Sean W. Limesand, Xiaochuan Chen
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Current Issues in Molecular Biology
Subjects:
epinephrine
insulin secretion
G proteins
uncoupling protein 2
sulphonylurea receptor 1
Online Access:https://www.mdpi.com/1467-3045/43/1/20

Internet

https://www.mdpi.com/1467-3045/43/1/20

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