Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism

Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism

Abstract Background Human mesenchymal stem/stromal cells (hMSCs) represent a promising therapeutic strategy for ventilator-induced lung injury (VILI) and acute respiratory distress syndrome. Translational challenges include restoring hMSC efficacy following cryopreservation, developing effective xen...

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Bibliographic Details
Main Authors: Shahd Horie, Sean Gaynard, Mary Murphy, Frank Barry, Michael Scully, Daniel O’Toole, John G. Laffey
Format: Article
Language:English
Published: SpringerOpen 2020-02-01
Series:Intensive Care Medicine Experimental
Subjects:
Acute respiratory distress syndrome
Ventilation-induced lung injury
Injury resolution and repair
Mesenchymal stem/stromal cells
Cryopreservation
Cell activation
Online Access:https://doi.org/10.1186/s40635-020-0295-5

Internet

https://doi.org/10.1186/s40635-020-0295-5

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