Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice

Evaluating the maintenance of disease-associated variation at the blood group-related gene B4galnt2 in house mice

Abstract Background B4galnt2 is a blood group-related glycosyltransferase that displays cis-regulatory variation for its tissue-specific expression patterns in house mice. The wild type allele, found e.g. in the C57BL/6 J strain, directs intestinal expression of B4galnt2, which is the pattern observ...

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Bibliographic Details
Main Authors: Marie Vallier, Maria Abou Chakra, Laura Hindersin, Miriam Linnenbrink, Arne Traulsen, John F. Baines
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Evolutionary Biology
Subjects:
B4galnt2
Blood group
Host-pathogen interaction
Balancing selection
Trade-off
Evolutionary game theory
Online Access:http://link.springer.com/article/10.1186/s12862-017-1035-7

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http://link.springer.com/article/10.1186/s12862-017-1035-7

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