Islet Insulin Secretion, β-Cell Mass, and Energy Balance in a Polygenic Mouse Model of Type 2 Diabetes With Obesity

Type 2 diabetes (T2D) and obesity are polygenic metabolic diseases, highly prevalent in humans. The TALLYHO/Jng (TH) mouse is a polygenic model of T2D and obesity that encompasses many aspects of the human conditions. In this study, we investigated the key metabolic components including β-cell physi...

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Bibliographic Details
Main Authors: Xia Mao MD, PhD, Kristy D. Dillon BS, Michael F. McEntee DVM, Arnold M. Saxton PhD, Jung Han Kim PhD
Format: Article
Language:English
Published: SciELO 2014-04-01
Series:Journal of Inborn Errors of Metabolism and Screening
Online Access:https://doi.org/10.1177/2326409814528153