An Improved Scoring Matrix for Multiple Sequence Alignment

The way for performing multiple sequence alignment is based on the criterion of the maximum-scored information content computed from a weight matrix, but it is possible to have two or more alignments to have the same highest score leading to ambiguities in selecting the best alignment. This paper ad...

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Bibliographic Details
Main Authors: Jian-Jun Shu, Kian Yan Yong, Weng Kong Chan
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Mathematical Problems in Engineering
Online Access:http://dx.doi.org/10.1155/2012/490649