Targeting Proteotoxic Stress in Cancer: A Review of the Role that Protein Quality Control Pathways Play in Oncogenesis

Targeting Proteotoxic Stress in Cancer: A Review of the Role that Protein Quality Control Pathways Play in Oncogenesis

Despite significant advances in cancer diagnostics and therapeutics the majority of cancer unfortunately remains incurable, which has led to continued research to better understand its exceptionally diverse biology. As a result of genomic instability, cancer cells typically have elevated proteotoxic...

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Bibliographic Details
Main Authors: Matthew Ho Zhi Guang, Emma L. Kavanagh, Luke Paul Dunne, Paul Dowling, Li Zhang, Sinéad Lindsay, Despina Bazou, Chia Yin Goh, Cathal Hanley, Giada Bianchi, Kenneth C. Anderson, Peter O’Gorman, Amanda McCann
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
proteotoxic stress
chemoresistance
proteasome
unfolded protein response
autophagy
multiple myeloma
triple negative breast cancer
protein quality control
Online Access:http://www.mdpi.com/2072-6694/11/1/66

Internet

http://www.mdpi.com/2072-6694/11/1/66

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