Astrocytic apoE4 and tau: Deadly combination for neurons
New data from Wang and colleagues1 suggest that astrocyte-derived apoE4 drives tau-mediated neurodegeneration. This research highlights how a genetic risk factor for Alzheimer’s disease is a major determinant of neurodegeneration in tau-expressing neurons by regulating non-cell-autonomous pathways....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-06-01
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| Series: | Cell Reports Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666379121001592 |