Induction of Identical IgG HIV-1 Envelope Epitope Recognition Patterns After Initial HIVIS-DNA/MVA-CMDR Immunization and a Late MVA-CMDR Boost

Induction of Identical IgG HIV-1 Envelope Epitope Recognition Patterns After Initial HIVIS-DNA/MVA-CMDR Immunization and a Late MVA-CMDR Boost

In the RV144 trial, to date the only HIV-1 vaccine efficacy trial demonstrating a modestly reduced risk of HIV-1 acquisition, antibody responses toward the HIV Envelope protein (Env) variable (V) 2 and V3 regions were shown to be correlated with a reduced risk of infection. These potentially protect...

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Bibliographic Details
Main Authors: Agricola Joachim, Mohamed I. M. Ahmed, Georgios Pollakis, Lisa Rogers, Verena S. Hoffmann, Patricia Munseri, Said Aboud, Eligius F. Lyamuya, Muhammad Bakari, Merlin L. Robb, Britta Wahren, Eric Sandstrom, Charlotta Nilsson, Gunnel Biberfeld, Christof Geldmacher, Kathrin Held
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
human immunodeficiency virus 1 (HIV-1)
vaccine
envelope (Env)
envelope-specific antibody response
epitope variants
immunogen structure
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00719/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00719/full

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