Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE).

Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE).

Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognit...

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Bibliographic Details
Main Authors: Ivonne Renner, Nancy Funk, Rene Geissler, Susann Friedrich, Anika Penzel, Sven-Erik Behrens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4255017?pdf=render

Internet

http://europepmc.org/articles/PMC4255017?pdf=render

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