Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives

Chemosensitization of multidrug resistant Candida albicans by the oxathiolone fused chalcone derivatives

Three structurally related oxathiolone fused chalcone derivatives appeared effective chemosensitizers, able to restore in part sensitivity to fluconazole of multidrug-resistant C. albicans strains. Compound 21 effectively chemosensitized cells resistant due to the overexpression of the MDR1 gene, co...

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Bibliographic Details
Main Authors: Izabela eŁącka, Marek T Konieczny, Anita eBułakowska, Marie eKodedova, Dana eGaskova, Indresh Kumar Maurya, Rajendra ePrasad, Slawomir eMilewski
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Microbiology
Subjects:
Candida albicans
Chalcones
multidrug resistance
antifungals
chemosensitization
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00783/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00783/full

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