Allele-specific amplification in cancer revealed by SNP array analysis.
Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly high resolution. Similarly, loss-of-heterozygosity events have been finely mapped using high-throughpu...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-11-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://dx.doi.org/10.1371/journal.pcbi.0010065 |