Therapeutic Interference With Vascular Calcification—Lessons From Klotho-Hypomorphic Mice and Beyond

Therapeutic Interference With Vascular Calcification—Lessons From Klotho-Hypomorphic Mice and Beyond

Medial vascular calcification, a major pathophysiological process associated with cardiovascular disease and mortality, involves osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs). In chronic kidney disease (CKD), osteo-/chondrogenic transdifferentiation of VSMCs and, t...

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Bibliographic Details
Main Authors: Florian Lang, Christina Leibrock, Lisann Pelzl, Meinrad Gawaz, Burkert Pieske, Ioana Alesutan, Jakob Voelkl
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Endocrinology
Subjects:
vascular calcification
bicarbonate
carbonic anhydrase inhibitors
magnesium
mineralocorticoid receptor
ammonium salts
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00207/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2018.00207/full

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