AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity

Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles of the endomembrane in regulating such pleiotropic...

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Bibliographic Details
Main Authors: Caroline M. Gorvin, Angela Rogers, Benoit Hastoy, Andrei I. Tarasov, Morten Frost, Silvia Sposini, Asuka Inoue, Michael P. Whyte, Patrik Rorsman, Aylin C. Hanyaloglu, Gerda E. Breitwieser, Rajesh V. Thakker
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Subjects:
clathrin-mediated endocytosis
adaptor protein-2
GPCR
calcium signaling
hypercalcemia
endosomal signaling
G proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717319265

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http://www.sciencedirect.com/science/article/pii/S2211124717319265

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